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Progress in Human andTetrahymenaTelomerase Structure Determination

16 Mar 2017

Abstract excerpt

Telomerase is an RNA-protein complex that extends the 3' ends of linear chromosomes, using a unique telomerase reverse transcriptase (TERT) and template in the telomerase RNA (TR), thereby helping to maintain genome integrity. TR assembles with TERT and species-specific proteins, and telomerase function in vivo requires interaction with telomere-associated proteins. Over the past two decades, structures of...

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Share to Advanced biosensing and bioanalysis techniques
Share to Telomeres, Telomerase, and Senescence
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PMID: 28301767
DOI: 10.1146/annurev-biophys-062215-011140

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