Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study.

doi:10.1002/mds.27989

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Article

Clinical and Dopamine Transporter Imaging Characteristics of Leucine Rich Repeat Kinase 2 (LRRK2) and Glucosylceramidase Beta (GBA) Parkinson's Disease Participants in the Parkinson's Progression Markers Initiative: A Cross-Sectional Study.

Movement disorders : official journal of the Movement Disorder Society - 1 May 2020

Simuni Tanya, Brumm Michael C, Uribe Liz, Caspell-Garcia Chelsea, Coffey Christopher S, Siderowf Andrew, Alcalay Roy N, Trojanowski John Q, Shaw Leslie M, Seibyl John, Singleton Andrew, Toga Arthur W, Galasko Doug, Foroud Tatiana, Nudelman Kelly, Tosun-Turgut Duygu, Poston Kathleen, Weintraub Daniel, Mollenhauer Brit, Tanner Caroline M, Kieburtz Karl, Chahine Lana M, Reimer Alyssa, Hutten Samantha, Bressman Susan, Marek Kenneth

Abstract excerpt

BACKGROUND: There are limited data on the phenotypic and dopamine transporter (DAT) imaging characterization of the Parkinson's disease (PD) patients with leucine rich kinase 2 (LRRK2) and glucosylceramidase beta (GBA) mutations. OBJECTIVE: The objective of this study was to examine baseline clinical and DAT imaging characteristics in GBA and LRRK2 mutation carriers with early PD compared with sporadic PD....

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PMID: 32073681
DOI: 10.1002/mds.27989
PMCID: PMC7231646

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