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Comparing the effects of GBA variants and onset age on clinical features and progression in Parkinson's disease.

CNS neuroscience & therapeutics - 1 Feb 2024

Ren Jingru, Zhan Xiaoyan, Zhou Hao, Guo Zhiying, Xing Yi, Yin Hangxing, Xue Chen, Wu Jun, Liu Weiguo

Abstract excerpt

OBJECTIVE: Glucosylceramidase (GBA) variants and onset age significantly affect clinical phenotype and progression in Parkinson's disease (PD). The current study compared clinical characteristics at baseline and cognitive and motor progression over time among patients having GBA-related PD (GBA-PD), early-onset idiopathic PD (early-iPD), and late-onset idiopathic PD (late-iPD). METHODS: We recruited 88 GBA-PD,...

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Identifiers

PMID: 37563866
DOI: 10.1111/cns.14387
PMCID: PMC10848098

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