CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors.

doi:10.1136/jitc-2020-001948

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Article

CXCR6 deficiency impairs cancer vaccine efficacy and CD8+ resident memory T-cell recruitment in head and neck and lung tumors.

Journal for immunotherapy of cancer - 1 Mar 2021

Karaki Soumaya, Blanc Charlotte, Tran Thi, Galy-Fauroux Isabelle, Mougel Alice, Dransart Estelle, Anson Marie, Tanchot Corinne, Paolini Lea, Gruel Nadege, Gibault Laure, Lepimpec-Barhes Francoise, Fabre Elizabeth, Benhamouda Nadine, Badoual Cecile, Damotte Diane, Donnadieu Emmanuel, Kobold Sebastian, Mami-Chouaib Fathia, Golub Rachel, Johannes Ludger, Tartour Eric

Abstract excerpt

BACKGROUND: Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their induction is associated to the response to anti-Programmed cell death protein 1 (PD-1)/Programmed death-ligand 1 (PD-L1) immunotherapy and the efficacy of cancer vaccines. Previous work by our group and others has shown that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33692218
DOI: 10.1136/jitc-2020-001948
PMCID: PMC7949477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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