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Article

Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer's disease and cancer.

Journal of translational medicine - 4 Aug 2023

Dong Zehua, Xu Mengli, Sun Xu, Wang Xiaosheng

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) and cancer are common age-related diseases, and epidemiological evidence suggests an inverse relationship between them. However, investigating the potential mechanism underlying their relationship remains insufficient. METHODS: Based on genome-wide association summary statistics for 42,034 AD patients and 609,951 cancer patients from the GWAS Catalog using the two-sample...

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Identifiers

PMID: 37542274
DOI: 10.1186/s12967-023-04357-3
PMCID: PMC10403895

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