Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction.

doi:10.1101/gad.353628.126

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Article

Targeting EZH2 oncogenic splicing: decoding the regulatory network and antisense correction.

Genes & development - 26 Aug 2026

Islam Md Rafikul, Nagar Preeti, McNaughton Naomi, Heeamoni Shabiha Afroj, Hasan Md Mahbub, Kandel Shila, Mukta Israt Jahan, Tsakiroglou Panagiotis, Dalton William Brian, Abdel-Wahab Omar, Krainer Adrian R, Rahman Mohammad Alinoor

Abstract excerpt

Recurrent mutations in splicing factors (SFs) have been established as crucial drivers of tumorigenesis in several types of blood cancer and are also common in a variety of solid tumors. Mutations change the RNA-binding preferences of SFs, promote global splicing alterations, and often generate erroneous mRNAs that are then degraded by nonsense-mediated mRNA decay (NMD). Consequently, several critical genes...

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Share to Cell Line, Tumor
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

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Identifiers

PMID: 42547267
DOI: 10.1101/gad.353628.126
PMCID: PMC13474417

Genes

SRSF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.