Germline variants at SOHLH2 influence multiple myeloma risk.

doi:10.1038/s41408-021-00468-6

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Article

Germline variants at SOHLH2 influence multiple myeloma risk.

Blood cancer journal - 19 Apr 2021

Duran-Lozano Laura, Thorleifsson Gudmar, Lopez de Lapuente Portilla Aitzkoa, Niroula Abhishek, Went Molly, Thodberg Malte, Pertesi Maroulio, Ajore Ram, Cafaro Caterina, Olason Pall I, Stefansdottir Lilja, Bragi Walters G, Halldorsson Gisli H, Turesson Ingemar, Kaiser Martin F, Weinhold Niels, Abildgaard Niels, Andersen Niels Frost, Mellqvist Ulf-Henrik, Waage Anders, Juul-Vangsted Annette, Thorsteinsdottir Unnur, Hansson Markus, Houlston Richard, Rafnar Thorunn, Stefansson Kari, Nilsson Björn

Abstract excerpt

Multiple myeloma (MM) is caused by the uncontrolled, clonal expansion of plasma cells. While there is epidemiological evidence for inherited susceptibility, the molecular basis remains incompletely understood. We report a genome-wide association study totalling 5,320 cases and 422,289 controls from four Nordic populations, and find a novel MM risk variant at SOHLH2 at 13q13.3 (risk allele frequency = 3.5%; odds...

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PMID: 33875642
DOI: 10.1038/s41408-021-00468-6
PMCID: PMC8055668

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