Article
Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.
Nature communications - 22 Jul 2015
Ziv Elad, Dean Eric, Hu Donglei, Martino Alessandro, Serie Daniel, Curtin Karen, Campa Daniele, Aftab Blake, Bracci Paige, Buda Gabriele, Zhao Yi, Caswell-Jin Jennifer, Diasio Robert, Dumontet Charles, Dudziński Marek, Fejerman Laura, Greenberg Alexandra, Huntsman Scott, Jamroziak Krzysztof, Jurczyszyn Artur, Kumar Shaji, Atanackovic Djordje, Glenn Martha, Cannon-Albright Lisa A, Jones Brandt, Lee Adam, Marques Herlander, Martin Thomas, Martinez-Lopez Joaquin, Rajkumar Vincent, Sainz Juan, Vangsted Annette Juul, Wątek Marzena, Wolf Jeffrey, Slager Susan, Camp Nicola J, Canzian Federico, Vachon Celine
Abstract excerpt
Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI:...
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