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Article

Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.

The Journal of cell biology - 17 Jan 2005

Croft Daniel R, Coleman Mathew L, Li Shuixing, Robertson David, Sullivan Teresa, Stewart Colin L, Olson Michael F

Abstract excerpt

Membrane blebbing during the apoptotic execution phase results from caspase-mediated cleavage and activation of ROCK I. Here, we show that ROCK activity, myosin light chain (MLC) phosphorylation, MLC ATPase activity, and an intact actin cytoskeleton, but not microtubular cytoskeleton, are required for disruption of nuclear integrity during apoptosis. Inhibition of ROCK or MLC ATPase activity, which protect...

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Identifiers

PMID: 15657395
DOI: 10.1083/jcb.200409049
PMCID: PMC2171584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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