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Article

Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2011

Kanda Hiroshi, Igaki Tatsushi, Okano Hideyuki, Miura Masayuki

Abstract excerpt

Caspase-independent cell death is known to be important in physiological and pathological conditions, but its molecular regulation is not well-understood. Eiger is the sole fly ortholog of TNF. The ectopic expression of Eiger in the developing eye primordium caused JNK-dependent but caspase-independent cell death. To understand the molecular basis of this Eiger-induced nonapoptotic cell death, we performed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22065747
DOI: 10.1073/pnas.1103242108
PMCID: PMC3223446

Genes

TNF

Provenance

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