Article
Design of artificial metalloenzymes for the reduction of nicotinamide cofactors.
Journal of inorganic biochemistry - 1 Jul 2021
Basle Mattias, Padley Henry A W, Martins Floriane L, Winkler Gerlof Sebastiaan, Jäger Christof M, Pordea Anca
Abstract excerpt
Artificial metalloenzymes result from the insertion of a catalytically active metal complex into a biological scaffold, generally a protein devoid of other catalytic functionalities. As such, their design requires efforts to engineer substrate binding, in addition to accommodating the artificial catalyst. Here we constructed and characterised artificial metalloenzymes using alcohol dehydrogenase as starting...
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