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Article

Understanding the Directed Evolution of a Natural-like Efficient Artificial Metalloenzyme.

The journal of physical chemistry. B - 12 Dec 2024

Mukherjee Anagh, Roy Subhendu

Abstract excerpt

The artificial metalloenzyme containing iridium in place of iron along with four directed evolution mutations C317G, T213G, L69V, and V254L in a natural cytochrome P450 presents an important milestone in merging the extraordinary efficiency of biocatalysts with the versatility of small molecule chemical catalysts in catalyzing a new-to-nature carbene insertion reaction. This is a show-stopper enzyme, as it...

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Identifiers

PMID: 39588805
DOI: 10.1021/acs.jpcb.4c06994

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