Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Two NMN Deamidase Mutants as Possible Probes for an NMN Biosensor.

International journal of molecular sciences - 13 Jun 2021

Camarca Alessandra, Minazzato Gabriele, Pennacchio Angela, Capo Alessandro, Amici Adolfo, D'Auria Sabato, Raffaelli Nadia

Abstract excerpt

Nicotinamide mononucleotide (NMN) is a key intermediate in the nicotinamide adenine dinucleotide (NAD+) biosynthesis. Its supplementation has demonstrated beneficial effects on several diseases. The aim of this study was to characterize NMN deamidase (PncC) inactive mutants to use as possible molecular recognition elements (MREs) for an NMN-specific biosensor. Thermal stability assays and steady-state...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Biosensing Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Kinetics

Share to Protein Multimerization

Share to Spectrometry, Fluorescence

Share to Temperature

Share to Tryptophan

Source

Open in PubMed Open full text

Identifiers

PMID: 34199271
DOI: 10.3390/ijms22126334
PMCID: PMC8231969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Two NMN Deamidase Mutants as Possible Probes for an NMN Biosensor.PMID 34199271Read ↗

Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.Semantic proximity Read ↗

Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency.Semantic proximity Read ↗

Nicotinamide N-methyltransferase as a potential marker for cancerSemantic proximity Read ↗

Identification of malic enzyme mutants depending on 1,2,3-triazole moiety-containing nicotinamide adenine dinucleotide analogs.Semantic proximity Read ↗

Design of artificial metalloenzymes for the reduction of nicotinamide cofactors.Semantic proximity Read ↗

Truncating the C terminus of formate dehydrogenase leads to improved preference to nicotinamide cytosine dinucleotide.Semantic proximity Read ↗

Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and OptimizationSemantic proximity Read ↗

Identification by mutational analysis of four critical residues in the molybdenum cofactor domain of eukaryotic nitrate reductase.Semantic proximity Read ↗

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.Semantic proximity Read ↗

Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro.Semantic proximity Read ↗

A D-2-hydroxyglutarate biosensor based on specific transcriptional regulator DhdR.Semantic proximity Read ↗

Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.