Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ARTS of p53-dependent mitochondrial apoptosis

1 Oct 2022

Abstract excerpt

The tumor-suppressive activity of p53 is largely attributed to its ability to induce cell death, including apoptosis, through transcription-dependent and transcription-independent mechanisms. On the one hand, nuclear p53 transcriptionally activates the expression of a myriad of pro-apoptotic BCL-2 family genes, such as NOXA, PUMA, BID, BAD, BIK, BAX, etc., whereas it inactivates the expression of anti-apoptotic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36565718
DOI: 10.1093/jmcb/mjac074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ARTS of p53-dependent mitochondrial apoptosisPMID 36565718Read ↗

Mitochondrial death functions of p53Semantic proximity Read ↗

Non-Canonical Cell Death Induced by p53Semantic proximity Read ↗

The Molecular Machinery Regulating Apoptosis Signal Transduction and its Implication in Human Physiology and PathophysiologiesSemantic proximity Read ↗

Targeting the p53 Pathway of ApoptosisSemantic proximity Read ↗

The role of p53 in apoptosis.Semantic proximity Read ↗

Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studiesSemantic proximity Read ↗

Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m6A modification and diverse cell death mechanismsSemantic proximity Read ↗

Bypassing the guardian: regulated cell death pathways in p53-mutant cancersSemantic proximity Read ↗

p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseasesSemantic proximity Read ↗

Molecular circuits of apoptosis regulation and cell division control: The survivin paradigmSemantic proximity Read ↗

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis.Semantic proximity Read ↗

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.