Article
Scube activity is necessary for Hedgehog signal transduction in vivo.
Developmental biology - 15 Aug 2012
Johnson Jacque-Lynne F A, Hall Thomas E, Dyson Jennifer M, Sonntag Carmen, Ayers Katie, Berger Silke, Gautier Philippe, Mitchell Christina, Hollway Georgina E, Currie Peter D
Abstract excerpt
The Hedgehog (HH) signaling pathway is a central regulator of embryonic development, controlling the pattern and proliferation of a wide variety of organs. Previous studies have implicated the secreted protein, Scube2, in HH signal transduction in the zebrafish embryo (Hollway et al., 2006; Kawakami et al., 2005; Woods and Talbot, 2005) although the nature of the molecular function of Scube2 in this process has...
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