Article
Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.
Human molecular genetics - 1 Jul 2006
Dorus Steve, Anderson Jeffrey R, Vallender Eric J, Gilbert Sandra L, Zhang Li, Chemnick Leona G, Ryder Oliver A, Li Weimin, Lahn Bruce T
Abstract excerpt
Sonic Hedgehog (SHH) is one of the most intensively studied genes in developmental biology. It is a highly conserved gene, found in species as diverse as arthropods and mammals. The mammalian SHH encodes a signaling molecule that plays a central role in developmental patterning, especially of the nervous system and the skeletal system. Here, we show that the molecular evolution of SHH is markedly accelerated in...
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