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Article

Genome-wide specificity of prime editors in plants.

Nature biotechnology - 1 Oct 2021

Jin Shuai, Lin Qiupeng, Luo Yingfeng, Zhu Zixu, Liu Guanwen, Li Yunjia, Chen Kunling, Qiu Jin-Long, Gao Caixia

Abstract excerpt

Although prime editors (PEs) have the potential to facilitate precise genome editing in therapeutic, agricultural and research applications, their specificity has not been comprehensively evaluated. To provide a systematic assessment in plants, we first examined the mismatch tolerance of PEs in plant cells and found that the editing frequency was influenced by the number and location of mismatches in the primer...

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PMID: 33859403
DOI: 10.1038/s41587-021-00891-x

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