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Article

Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency

29 May 2023

Abstract excerpt

Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies defined an optimal primer binding site (PBS) length for the pegRNA of ∼13 nucleotides depending on the sequence composition. However, optimal PBS length characterization has been based on prime editing outcomes using plasmid or lentiviral expression systems. In this...

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PMID: 37246708
DOI: 10.1093/nar/gkad456

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