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Article

Optimized prime editing efficiently generates heritable mutations in maize.

Journal of integrative plant biology - 1 Apr 2023

Qiao Dexin, Wang Junya, Lu Min-Hui, Xin Cuiping, Chai Yiping, Jiang Yuanyuan, Sun Wei, Cao Zhenghong, Guo Siyi, Wang Xue-Chen, Chen Qi-Jun

Abstract excerpt

Low efficiency is the main obstacle to using prime editing in maize (Zea mays). Recently, prime-editing efficiency was greatly improved in mammalian cells and rice (Oryza sativa) plants by engineering prime-editing guide RNAs (pegRNAs), optimizing the prime editor (PE) protein, and manipulating cellular determinants of prime editing. In this study, we tested PEs optimized via these three strategies in maize. We...

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PMID: 36478403
DOI: 10.1111/jipb.13428

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