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Article

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.

Scientific reports - 12 Aug 2014

Yin Shanye, Yang Jing, Lin Bin, Deng Wenjun, Zhang Yuchao, Yi Xianfu, Shi Yufang, Tao Yong, Cai Jun, Wu Chung-I, Zhao Guoping, Hurst Laurence D, Zhang Jie, Hu Landian, Kong Xiangyin

Abstract excerpt

Lung cancer is the most common cause of cancer mortality worldwide, with an estimated 1.4 million deaths each year. Here we report whole-exome sequencing of nine tumor/normal tissue pairs from Chinese patients with non-small cell lung carcinoma (NSCLC). This allows us to identify a number of significantly mutated genes in NSCLC, which were highly enriched in DNA damage repair, NF-κB pathway, JAK/STAT signaling...

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PMID: 25112956
DOI: 10.1038/srep06036
PMCID: PMC5381403

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