Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KMT2D Mutation Is Associated With Poor Prognosis in Non-Small-Cell Lung Cancer.

Clinical lung cancer - 1 Jul 2018

Ardeshir-Larijani Fatemeh, Bhateja Priyanka, Lipka Mary Beth, Sharma Neelesh, Fu Pingfu, Dowlati Afshin

Abstract excerpt

BACKGROUND: Mixed-lineage leukemia protein 2 (MLL2 or KMT2D) is a histone methyltransferase whose mutation has been associated with a poor prognosis in cancer. We compared the characteristics and significance of KMT2D alterations in non-small-cell lung cancer (NSCLC) with those in small cell lung cancer (SCLC). PATIENTS AND METHODS: Tumors from 194 NSCLC patients with locally advanced or advanced disease and 64...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kaplan-Meier Estimate

Share to Lung Neoplasms

Share to Neoplasm Proteins

Share to Proportional Hazards Models

Share to Small Cell Lung Carcinoma

Share to Treatment Outcome

Source

Identifiers

PMID: 29627316
DOI: 10.1016/j.cllc.2018.03.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KMT2D Mutation Is Associated With Poor Prognosis in Non-Small-Cell Lung Cancer.PMID 29627316Read ↗

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.Semantic proximity Read ↗

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.Semantic proximity Read ↗

Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.Semantic proximity Read ↗

Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity Read ↗

Association between methyltransferase-like 3 and non-small cell lung cancer: pathogenesis, therapeutic resistance, and clinical applicationsSemantic proximity Read ↗

KMT2D mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-induced regulatory T cell trafficking via FBXW7-NOTCH-MYC/TGF-β1 axis.Semantic proximity Read ↗

KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.Semantic proximity Read ↗

A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in CancerSemantic proximity Read ↗

Bioinformatic analysis of methyltransferase-like protein family reveals clinical and functional outcomes in human cancerSemantic proximity Read ↗

DNA methyltransferase 3A (DNMT3A) mutations and PD-(L)1 blockade efficacy in non-small-cell lung cancer.Semantic proximity Read ↗

Aberrant Activity of Histone-Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis.Semantic proximity Read ↗

KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.