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Article

Genetic polymorphisms of human hepatic OATPs: functional consequences and effect on drug pharmacokinetics

10 Jun 2019

Abstract excerpt

1. Organic anion transporting polypeptides (OATPs) belong to the superfamily of solute carriers (SLC), which are important membrane transporters in animals and humans. Liver is an important organ for drug disposition. In human liver, three OATPs, namely OATP1B1, 1B3 and 2B1, are expressed on the basolateral membrane of hepatocytes.2. OATPs have multiple substrate specificity, mediating transport of a wide range...

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PMID: 31180267
DOI: 10.1080/00498254.2019.1629043

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