Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.

doi:10.2133/dmpk.22.456

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Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B117 is more prevalent than 15.

Drug metabolism and pharmacokinetics - 1 Dec 2007

Kim Su-Ryang, Saito Yoshiro, Sai Kimie, Kurose Kouichi, Maekawa Keiko, Kaniwa Nahoko, Ozawa Shogo, Kamatani Naoyuki, Shirao Kuniaki, Yamamoto Noboru, Hamaguchi Tetsuya, Kunitoh Hideo, Ohe Yuichiro, Yamada Yasuhide, Tamura Tomohide, Yoshida Teruhiko, Minami Hironobu, Ohtsu Atsushi, Saijo Nagahiro, Sawada Jun-ichi

Abstract excerpt

A liver-specific transporter organic anion transporting polypeptide 1B1 (OATP1B1, also known as OATP-C) is encoded by SLCO1B1 and mediates uptake of various endogenous and exogenous compounds from blood into hepatocytes. In this study, 15 SLCO1B1 exons (including non-coding exon 1) and their flanking introns were comprehensively screened for genetic variations in 177 Japanese subjects. Sixty-two genetic...

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PMID: 18159134
DOI: 10.2133/dmpk.22.456

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