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Article

Human APOB-expressing mice translate molecular phenotypes across the Alzheimer's disease spectrum.

Brain, behavior, and immunity - 1 Aug 2026

Aumont-Rodrigue Gabriel, Poirier Alexandre, Picard Cynthia, Poirier Judes

Abstract excerpt

BACKGROUND: Apolipoprotein B (APOB), a structural component of low-density lipoproteins (LDL), has historically been associated with peripheral lipid transport and cardiovascular disease. Recent studies have revealed a link between APOB and Alzheimer's disease (AD), with increased cerebrospinal fluid (CSF) APOB levels correlating with tau pathology. Although APOB is known to be locally expressed in the brain,...

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Source

Identifiers

PMID: 41935644
DOI: 10.1016/j.bbi.2026.106575

Genes

APOB
CRK
CTSD
SULT4A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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