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Article

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia.

Cell death & disease - 3 May 2022

Wang Yaping, Ma Xiaopeng, Huang Jie, Yang Xiaoyun, Kang Meiyun, Sun Xiaoyan, Li Huimin, Wu Yijun, Zhang Heng, Zhu Yuting, Xue Yao, Fang Yongjun

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common malignant hematological diseases in children. An immunosuppressive microenvironment, particularly regulatory T cell (Treg) infiltration, has been documented to be highly associated with childhood ALL. This present study, based on genetic factors, was aimed at investigating the mutations potentially involved in the immunosuppressive microenvironment in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35504885
DOI: 10.1038/s41419-022-04873-y
PMCID: PMC9065155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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