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Article

Variants of uncertain significance (VUS) in cancer predisposing genes: What are we learning from multigene panels?

European journal of medical genetics - 1 Jan 2022

Lucci-Cordisco Emanuela, Amenta Simona, Panfili Arianna, Del Valle Jesús, Capellá Gabriel, Pineda Marta, Genuardi Maurizio

Abstract excerpt

One of the main factors influencing the clinical utility of genetic tests for cancer predisposition is the ability to provide actionable classifications (ie pathogenic or benign). However, a large fraction of the variants identified in cancer predisposing genes (CPGs) are of uncertain significance (VUS), and cannot be used for clinical purposes either to identify individuals at risk or to drive treatment. Here we...

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PMID: 34813939
DOI: 10.1016/j.ejmg.2021.104400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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