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Article

A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.

Biochemical and biophysical research communications - 4 Jun 2021

Watanabe Masaki, Takahashi Yuki, Hiura Koki, Nakano Kenta, Okamura Tadashi, Sasaki Hayato, Sasaki Nobuya

Abstract excerpt

Adriamycin (ADR)-induced nephropathy is frequently utilized in rodent models of podocytopathy. However, the application of this model in mice is limited to a few strains, such as BALB/c mice. The most commonly used mouse strain, C57BL/6 (B6), is resistant to ADR-induced nephropathy, as are all mouse strains with a B6 genetic background. Reportedly, the R2140C variant of the Prkdc gene is the cause of...

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PMID: 33839407
DOI: 10.1016/j.bbrc.2021.03.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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