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Article

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice.

The Journal of clinical investigation - 1 Nov 2010

Papeta Natalia, Zheng Zongyu, Schon Eric A, Brosel Sonja, Altintas Mehmet M, Nasr Samih H, Reiser Jochen, D'Agati Vivette D, Gharavi Ali G

Abstract excerpt

Adriamycin (ADR) is a commonly used chemotherapeutic agent that also produces significant tissue damage. Mutations to mitochondrial DNA (mtDNA) and reductions in mtDNA copy number have been identified as contributors to ADR-induced injury. ADR nephropathy only occurs among specific mouse inbred strains, and this selective susceptibility to kidney injury maps as a recessive trait to chromosome 16A1-B1. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20978358
DOI: 10.1172/JCI43721
PMCID: PMC2964992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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