Article
The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.
Kidney international - 1 Jun 2021
Arroyo Jennifer, Escobar-Zarate Diana, Wells Harrison H, Constans Megan M, Thao Ka, Smith Jessica M, Sieben Cynthia J, Martell Madeline R, Kline Timothy L, Irazabal Maria V, Torres Vicente E, Hopp Katharina, Harris Peter C
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2 mutations, causes progressive kidney cyst development and kidney failure. There is significant intrafamilial variability likely due to the genetic background and environmental/lifestyle factors; variability that can be modeled in PKD mice. Here, we characterized mice homozygous for the PKD1 hypomorphic allele, p.Arg3277Cys...
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