Article
SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants.
Computers in biology and medicine - 1 Mar 2024
Hassan Sk Sarif, Bhattacharya Tanishta, Nawn Debaleena, Jha Ishana, Basu Pallab, Redwan Elrashdy M, Lundstrom Kenneth, Barh Debmalya, Andrade Bruno Silva, Tambuwala Murtaza M, Aljabali Alaa A, Hromić-Jahjefendić Altijana, Baetas-da-Cruz Wagner, Serrano-Aroca Ángel, Uversky Vladimir N
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional Nonstructural protein 14 (NSP14) enzyme, possessing exonuclease and messenger RNA (mRNA) capping capabilities, serves as a key player. Notably, single and co-occurring mutations within NSP14 significantly influence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.