Article

SARS-CoV-2 NSP14 governs mutational instability and assists in making new SARS-CoV-2 variants

2023-09-29

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the rapidly evolving RNA virus behind the COVID-19 pandemic, has spawned numerous variants since its 2019 emergence. The multifunctional NSP14 enzyme, possessing exonuclease and mRNA capping capabilities, serves as a key player. Notably, single and co-occurring mutations within NSP14 significantly influence replication fidelity and drive variant diversi...

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Literature Corpus work: 87a677c4-9722-5e2d-9b0b-55c949f0dc67
DOI: 10.1101/2023.09.28.559966

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