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Article

Resolving the Synaptic versus Developmental Dichotomy of Autism Risk Genes.

Trends in neurosciences - 1 Apr 2020

Heavner Whitney E, Smith Stephen E P

Abstract excerpt

Genes that are mutated in Autism Spectrum Disorders (ASD) can be classified broadly as either synaptic or developmental. But what if this is a false distinction? A recent spate of publications has provided evidence for developmental mechanisms that rely on neural activity for proper cortical development. Conversely, a growing body of evidence indicates a role for developmental mechanisms, particularly chromatin...

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Identifiers

PMID: 32209454
DOI: 10.1016/j.tins.2020.01.009
PMCID: PMC7101276

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