Article
Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.
Proceedings of the National Academy of Sciences of the United States of America - 5 May 2026
Wang Qian, Chen Min, Lasram Asma, Vihuri Saana, Chou Angela Z, Bian Weixin, Dai Zhiming, Haapanen Outi, Enkavi Giray, Pollmann Christoph, Vattulainen Ilpo, Cai Tiantian, Piehler Jacob, Chou James J
Abstract excerpt
Mutations within the transmembrane domains (TMDs) of single-pass transmembrane receptors often cause aberrant, ligand-independent receptor signaling associated with diverse malignancies, but their mechanism of action remains largely unknown. These TMD mutations are generally not targetable as they are buried in the membrane. Here, we determined the mechanism of a gain-of-function (GOF) TMD mutation of...
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