Risks of Macrosomia Associated with Catechol-O-Methyltransferase Genotypes and Genetic-Epigenetic Interactions among Children with and without Gestational Diabetes Exposure.

doi:10.1089/chi.2020.0327

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Risks of Macrosomia Associated with Catechol-O-Methyltransferase Genotypes and Genetic-Epigenetic Interactions among Children with and without Gestational Diabetes Exposure.

Childhood obesity (Print) - 1 Jul 2021

Aguayo Liliana, Li Weiqin, Joyce Brian T, Leng Junhong, Zheng Yinan, Shiau Stephanie, Liu Huikun, Wang Leishen, Gao Ru, Baccarelli Andrea, Hu Gang, Hou Lifang

Abstract excerpt

Background: Gestational diabetes mellitus (GDM) is a major macrosomia risk factor. Variations in the catechol-O-methyltransferase (COMT; rs4680) genotypes are associated with heightened susceptibility to environmental exposures and nutritional conditions. However, macrosomia risks associated with COMT genetics, epigenetics, and the interaction between genetic and epigenetics among children with and without...

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Identifiers

PMID: 33826421
DOI: 10.1089/chi.2020.0327
PMCID: PMC8236387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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