Article
Catechol-O-methyltransferase association with hemoglobin A1c.
Metabolism: clinical and experimental - 1 Jul 2016
Hall Kathryn T, Jablonski Kathleen A, Chen Ling, Harden Maegan, Tolkin Benjamin R, Kaptchuk Ted J, Bray George A, Ridker Paul M, Florez Jose C, Mukamal Kenneth J, Chasman Daniel I
Abstract excerpt
AIMS: Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Here we examined COMT effects on glycemic function and type 2 diabetes. METHODS: We tested whether COMT polymorphisms were...
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