Article
Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children.
Journal of toxicology and environmental health. Part A - 1 Jan 2014
Woods James S, Heyer Nicholas J, Russo Joan E, Martin Michael D, Pillai Pradeep B, Bammler Theodor K, Farin Federico M
Abstract excerpt
Mercury (Hg) is neurotoxic and children may be particularly susceptible to this effect. A current major challenge is identification of children who may be uniquely susceptible to Hg toxicity because of genetic disposition. This study examined the hypothesis that genetic variants of catechol-O-methyltransferase (COMT) that are reported to alter neurobehavioral functions that are also affected by Hg in adults might...
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