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Article

Novel epigenetic link between gestational diabetes mellitus and macrosomia.

Epigenomics - 1 Aug 2021

Joyce Brian T, Liu Huikun, Wang Leishen, Wang Jun, Zheng Yinan, Nannini Drew, Drong Alex, Shiau Stephanie, Li Weiqin, Leng Junhong, Shen Yun, Gao Ru, Baccarelli Andrea, Hu Gang, Hou Lifang

Abstract excerpt

Background & objectives: Examine maternal gestational diabetes mellitus (GDM), macrosomia and DNA methylation in candidate genes IGF1, IGF2, H19, ARHGRF11, MEST, NR3C1, ADIPOQ and RETN. Materials & methods: A total of 1145 children (572 GDM cases and 573 controls) from the Tianjin GDM study, including 177 with macrosomia, had blood DNA collection at median age 5.9 (range: 3.1-10.0). We used logistic regression to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34337972
DOI: 10.2217/epi-2021-0096
PMCID: PMC8371577

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