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Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2021

Men Hongsheng, Hankins Miriam A, Bock Anagha S, Beaton Benjamin P, Davis Daniel J, Chesney Kari L, Bryda Elizabeth C

Abstract excerpt

Mutations and single base pair polymorphisms in various genes have been associated with increased susceptibility to inflammatory bowel disease (IBD). We have created a series of rat strains carrying targeted genetic alterations within three IBD susceptibility genes: Nod2, Atg16l1, and Il23r, using CRISPR/Cas9 genome editing technology. Knock-out alleles and alleles with known human susceptibility polymorphisms...

Topics

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CRISPR-Cas Systems
Gene Editing
Inflammatory Bowel Diseases
Nod2 Signaling Adaptor Protein
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Interleukin

Vesicular Transport Proteins

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Open in PubMed Open full text

Identifiers

PMID: 33843019
DOI: 10.1007/s00335-021-09868-2
PMCID: PMC8128796

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