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Article

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.

Molecular oncology - 1 Oct 2021

Kim Jin K, Marco Michael R, Choi Seo-Hyun, Qu Xuan, Chen Chin-Tung, Elkabets Moshe, Fairchild Lauren, Chow Oliver, Barriga Francisco M, Dow Lukas E, O'Rourke Kevin, Szeglin Bryan, Yarilin Dmitry, Fujisawa Sho, Manova-Todorova Katia, Paty Philip B, Shia Jinru, Leslie Christina, Smith J Joshua, Lowe Scott, Pelossof Raphael, Sanchez-Vega Francisco, Garcia-Aguilar Julio

Abstract excerpt

Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully understood. We profiled mRNA in 76 locally advanced rectal adenocarcinomas from patients that were enrolled in a prospective clinical trial and investigated differences in gene expression between KRAS mutant (KRAS-mt) and KRAS-wild-type (KRAS-wt) patients....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33817986
DOI: 10.1002/1878-0261.12960
PMCID: PMC8486594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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