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Article

Impact of KRAS status on tumor response and survival after neoadjuvant treatment of locally advanced rectal cancer.

Journal of surgical oncology - 1 Jan 2021

Zhou Peige, Goffredo Paolo, Ginader Timothy, Thompson Dakota, Hrabe Jennifer, Gribovskaja-Rupp Irena, Kapadia Muneera, Hassan Imran

Abstract excerpt

BACKGROUND: Mutation of the KRAS oncogene (mKRAS) in colorectal cancer has been associated with aggressive tumor biology, resistance to epidermal growth factor inhibitors, and decreased overall survival (OS). The aim of the current study was to analyze the association of mKRAS with pathologic complete response (pCR) and neoadjuvant rectal (NAR) score, and its impact on the survival of patients with locally...

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PMID: 33022750
DOI: 10.1002/jso.26244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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