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[Methodological Research on Rapid Detection and Genotyping of NPM1 Gene Mutations in Leukemia].

Zhongguo shi yan xue ye xue za zhi - 1 Apr 2021

Chen Chao, Lin Jun, Long Kai, Yang Yu-Chun, Li Zhi-Peng

Abstract excerpt

OBJECTIVE: To establish a method for rapid detection and typing of NPM1 mutations in acute myeloid leukemia (AML) by fluorescence melting curve analysis technology. METHODS: A pair of primers and a fluorescent single-stranded probe (molecule beacon) were designed for the mutant genes mutA, mutB, mutD in exon 12 of nucleopsin (NPM1) and wild type. With a real-time qPCR, the A, B, and D gene mutations of NPM1 were...

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Identifiers

PMID: 33812406
DOI: 10.19746/j.cnki.issn.1009-2137.2021.02.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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