Article
Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia.
International journal of hematology - 1 Aug 2007
Yan Lingzhi, Chen Suning, Liang Jianying, Feng Yufeng, Cen Jiannong, He Jun, Chang Weirong, Zhu Ziling, Pan Jinlan, Wu Yafang, Xue Yongquan, Wu Depei
Abstract excerpt
Many European groups have recently described that mutations at exon-12 of the nucleophosmin (NPM1) gene are the most frequent genetic lesion in patients with acute myeloid leukemia (AML), especially in the presence of a normal karyotype. This study explored the prevalence and clinical profile of NPM1 mutations in a cohort of 156 Chinese adults with AML. NPM1 exon-12 mutations were detected using direct sequencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.