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[Detection of NPM1 Mutation in Acute Myeloid Leukemia by Droplet Digital PCR and Its Clinical Application Value].

Zhongguo shi yan xue ye xue za zhi - 1 Jun 2022

Jin Ye, Wang Shi Sen, Xia Pei Hui, Yuan Qian, Xiao Gao Fei, Lin Jiang, Leng Jia Yan, Ma Yu Juan, Qian Jun

Abstract excerpt

OBJECTIVE: To establish the droplet digital PCR (ddPCR) assay for the detection of NPM1 type A mutation in patients with acute myeloid leukemia (AML), and to evaluate its specificity, sensitivity and its value in clinical application. METHODS: NPM1 mutant and wildtype plasmids were used to verify the performance of ddPCR. Both ddPCR and Sanger sequencing were used to detect the bone marrow samples of 87 AML...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35680787
DOI: 10.19746/j.cnki.issn.1009-2137.2022.03.001

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