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[Analysis of NPM1 gene mutations in acute myeloid leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 May 2007

Yan Ling-zhi, Chen Su-ning, Liang Jian-ying, Feng Yu-feng, Cen Jian-nong, He Jun, Chang Wei-rong, Zhu Zi-ling, Pan Jin-lan, Wu Ya-fang, Xue Yong-quan, Wu De-pei

Abstract excerpt

OBJECTIVE: To evaluate the prevalence of nucleophosmin (NPM1) gene exon 12 mutations in adults with acute myeloid leukemia (AML) and its clinical characteristics. METHODS: Genomic DNAs from 101 AML adults were screened by PCR and sequencing or capillary electrophoresis (CE) for NPMI mutations. RESULTS: NPM1 exon 12 mutations were present in 31.7% of the overall cohort, including 1/1 (100%) of M0, 9/17(52.9%) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17877154

Genes

NPM1

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