Article

Endogenous adenine is a potential driver of the cardiovascular-kidney-metabolic syndrome

2024-08-20

Abstract excerpt

Mechanisms underlying the cardiovascular-kidney-metabolic (CKM) syndrome are unknown, although key small molecule metabolites may be involved. Bulk and spatial metabolomics identified adenine to be upregulated and specifically enriched in coronary blood vessels in hearts from patients with diabetes and left ventricular hypertrophy. Single nucleus gene expression studies revealed that endothelial methylthioadenosin...

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Literature Corpus work: 0d29e9ea-8dbf-5c24-be75-a8cc0279bf8c
DOI: 10.1101/2024.08.19.24312277

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