Untargeted metabolomics analysis of differences in metabolite levels in congenital heart disease of varying severity

Abstract excerpt

<h4>Background: </h4> Congenital heart disease (CHD) is characterized by various phenotypes, however, differences in metabolic profiles associated with CHD of various severity have not been elucidated. In this study, differences in metabolite concentrations among mild, moderate, and severe forms of CHD were explored, providing novel clues for our understanding of the mechanism of CHD. Methods Maternal amniotic fl...

Topics

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• Cell Culture Techniques
• Congenital Heart Disease Studies
• Disease Models, Animal
• Heart Defects, Congenital
• High-Throughput Nucleotide Sequencing
• Mice
• Phenotype
• Pulmonary Hypertension Research and Treatments

Identifiers and source

Literature Corpus work

19f0ed2d-7d7d-517c-bbbc-282724b5ac78

DOI

10.21203/rs.3.rs-2464935/v1