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Article

Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions.

Journal of molecular biology - 25 Jun 2021

Kelly Colleen, Pace Nicola, Gage Matthew, Pfuhl Mark

Abstract excerpt

Titin, the largest single chain protein known so far, has long been known to play a critical role in passive muscle function but recent studies have highlighted titin's role in active muscle function. One of the key elements in this role is the Ca2+-dependent interaction between titin's N2A region and the thin filament. An important element in this interaction is I83, the terminal immunoglobulin domain in the N2A...

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Identifiers

PMID: 33811919
DOI: 10.1016/j.jmb.2021.166977
PMCID: PMC9550216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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