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Article

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.

The Journal of biological chemistry - 7 Aug 2015

He Yanan, Rangarajan Sneha, Kerzic Melissa, Luo Ming, Chen Yihong, Wang Qian, Yin Yiyuan, Workman Creg J, Vignali Kate M, Vignali Dario A A, Mariuzza Roy A, Orban John

Abstract excerpt

The T cell receptor (TCR)-CD3 complex is composed of a genetically diverse αβ TCR heterodimer associated noncovalently with the invariant CD3 dimers CD3ϵγ, CD3ϵδ, and CD3ζζ. The TCR mediates peptide-MHC recognition, whereas the CD3 molecules transduce activation signals to the T cell. Although much is known about downstream T cell signaling pathways, the mechanism whereby TCR engagement by peptide-MHC initiates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Folding

Share to Protein Multimerization

Share to Protein Structure, Secondary

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 26109064
DOI: 10.1074/jbc.M115.663799
PMCID: PMC4528140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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