Article

Human calpain-3 and its structural plasticity: dissociation of a homohexamer into dimers on binding titin

2024-03-03

Abstract excerpt

Calpain-3 is an intracellular Ca 2+ -dependent cysteine protease abundant in skeletal muscle. Its physiological role in the sarcomere is thought to include removing damaged muscle proteins after exercise. Loss-of-function mutations in its single-copy gene cause a dystrophy of the limb-girdle muscles. These mutations, of which there are over 500 in humans, are spread all along this 94-kDa multi-domain protein that...

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Literature Corpus work: d26768b5-31bd-584b-83ab-d6e194b58014
DOI: 10.1101/2024.02.28.582628

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