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Article

Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation.

International journal of molecular sciences - 12 Mar 2021

Clarke Joseph-Patrick W E, Thibault Patricia A, Salapa Hannah E, Kim David E, Hutchinson Catherine, Levin Michael C

Abstract excerpt

Evidence indicates that dysfunctional heterogeneous ribonucleoprotein A1 (hnRNPA1; A1) contributes to the pathogenesis of neurodegeneration in multiple sclerosis. Understanding molecular mechanisms of neurodegeneration in multiple sclerosis may result in novel therapies that attenuate neurodegeneration, thereby improving the lives of MS patients with multiple sclerosis. Using an in vitro, blue light induced,...

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Identifiers

PMID: 33809384
DOI: 10.3390/ijms22062909
PMCID: PMC7998649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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